Investing in Knit Health: Clinical Intelligence of the Future

For all the extraordinary advances in medicine over the last several decades, one truth remains surprisingly persistent: healthcare is still incredibly difficult to navigate.

Even when the right treatment is known, delivering that care consistently and efficiently remains frustratingly hard. Patients struggle to navigate fragmented systems, clinicians face mounting administrative burden, and health systems operate under constant resource constraints. Successful outcomes are still largely dependent on the talents of highly experienced clinicians, but so much of the modern healthcare experience is spent wandering the administrative desert of medicine in search of the right doctor.  

That’s why we’re excited to share that Uncork Capital led Knit Health’s $11.6 million seed round alongside our friends at Frist Cressey Ventures, Moxxie Ventures, and Coalition Operators.

Knit has developed a Large Clinical Behavior Model (LCBM), a novel foundational model designed to learn not just from medical text, but from how care is actually delivered in practice. In partnership with Truveta (a consortium of EHR data from over 30 US health systems and more than 130 million patients), the company is training models on real clinical decision-making patterns: how patients are routed, how clinicians coordinate care, and how complex healthcare systems operate under real-world constraints.

Over the last several decades, technology has produced constant, but incremental improvements to clinical healthcare. We feel that Knit is on the precipice of delivering a series of step-function advances by improving patient flow, reducing inefficiencies, helping clinicians make better decisions faster, and ultimately improving patient outcomes at scale. This will lead to better patient outcomes, reduced burdens on doctors, and significantly lower costs across healthcare systems.

The foundation of our conviction is Knit’s founding team. Led by Jonathan Kolstad, a multi-time founder and the Henry J. Kaiser Chair at the Haas School of Business, UC Berkeley, the company has assembled an exceptional team that brings together expertise across behavioral economics, causal inference, generative AI, and clinical operations, giving them a uniquely interdisciplinary perspective on one of healthcare’s hardest challenges. What impressed us most was not only the ambition of the vision, but the team’s appreciation for the complexity and responsibility that comes with deploying AI in healthcare. This is a domain where trust, reliability, and thoughtful implementation matter enormously.

We believe the most important healthcare AI companies of the next decade will become foundational infrastructure for how care is delivered and coordinated. Knit has the potential to become one of those companies. We’re excited to partner with Jonathan and the entire Knit team on that journey.